Fig. 3From: Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organizationGlucocorticoid receptor (GR)-dependent and p65 activation-dependent changes in chromatin interactions. a, b Direct comparison of chromatin contacts revealed by P300 ChIA-PET and 4C-seq analyses at the ZBTB16 (a) and KLF6 loci (b). 4C-seq bait loci are marked on each screenshot (blue arrow). Genomic regions that show a marked change in 4C signal upon triamcinolone acetonide (TA) + tumor necrosis factor alpha (TNFα) treatment are marked red below the Δ4C track. c Direct comparison of changes in average ChIP-seq signal (left panel) and 4C signal (right panel) at all the constitutive P300 distal binding sites (DBSs) within the ten 4C-seq genomic view points upon TA + TNFα treatment. d Direct comparison of changes in average ChIP-seq signal (left panel) and 4C signal (right panel) at all the induced P300 DBSs within the ten 4C-seq genomic view points upon TA + TNFα treatment. DMSO dimethyl sulfoxideBack to article page