Fig. 1
From: Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization
Activated glucocorticoid receptor (GR) recruits P300 to epigenomically latent genomic regions. a Color profile depicting the GR and P300 signal at all GR-bound regions with either constitutive or ligand (triamcinolone acetonide [TA]) -induced P300 occupancy. b Example screenshot depicting the TA-induced P300 distal binding site (DBS; dotted box) and constitutive P300 DBS. c Basal (untreated cells) H3K27ac, DNase I hypersensitive site, and H3K4me1 signal at all GR-induced and constitutive P300 DBSs. d Motif occurrence at all GR-bound DBSs presented as a function of TA-dependent P300 recruitment (x-axis). DMSO dimethyl sulfoxide, RE response elements