Fig. 1
From: HiC-Pro: an optimized and flexible pipeline for Hi-C data processing
Comparison of HiC-Pro and hiclib processing. a Both pipelines generate concordant results across processing steps. The fraction of uniquely aligned read pairs is calculated on the total number of initial reads. Self-circle and dangling-end fractions are calculated on the total number of aligned read pairs. Intra- and inter-chromosomal contacts are calculated as a fraction of filtered valid interactions. b Boxplots of the Spearman correlation coefficients of intra- and inter-chromosomal maps generated at different resolutions by both pipelines. c Chromosome 6 contact maps generated by hiclib (top) and HiC-Pro (bottom) at different resolutions. The chromatin interaction data generated by the two pipelines are highly similar