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Table 2 Detection of HSE in TFs up-regulated during response of the genome to misfolded myosin

From: Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells

Name

Cluster

Padj

Hsf1 sequence

Position

24-hpf expression

Human ChIP peak

CREB3L3

1

4.9E-15

TCTCCAGAAACATCC

1973–1987 (intron)

Not restricted

Yes

myod1

1

1.5E-04

GTTCTGGAACATTAC

1658–1672 (exon1)

Somite

No

mxtx1

1

1.6E-05

TTTCAAGAAATTTCT

574–588 (promoter)

Not restricted

No ortholog

zgc:113263

1

4.9E-05

CTTCCTGAAGTTTCG

659–673 (promoter)

Not restricted

No ortholog

atf5b

4

1.4E-04

TTTCTAGAGACTTCC

1295–1309 (intron)

NA

Yes

nfe2l1

4

2.3E-05

TTTCCAGAATATTTT

876–890 (promoter)

Not restricted

Yes

AL929286.1

4

8.5E-17

TGTCCAGCACCTTCT

1278–1292 (exon1)

NA

No ortholog

znf395a

4

5.1E-34

TTTCTAGAACATTAT

178–192 (promoter)

Not restricted

No

   

TTTCTAAAACATTCC

1880–1894 (intron)

  

tfe3a

4

3.1E-06

TTTGCAGAATCTTCC

250–264 (promoter)

Blood, YSL, lens

No

stat5.1

6

1.4E-02

ATTCCGGAAGCTTCT

341–355 (promoter)

Somite

Yes

tcf3

6

4.3E-03

TCTCTGGCAAATTCT

328–342 (promoter)

Not restricted

Yes

hoxc1a

6

1.5E-02

CTTTCAGAACTTTCT

1359–1373 (exon1)

Spinal cord

Yes

klf15

6

7.3E-03

TTTCCAGAATTTTTT

330–344 (promoter)

Somite

Yes

neurog1

6

2.2E-02

TTTCTGGCGTATTCC

1180–1194 (intron)

Nervous system

Yes

vox

6

4.5E-02

TTTCTGAAATATTCT

1550–1564 (intron)

Not restricted

No

sim1a

6

3.6E-02

TTTCTTGAAGTCTCT

957–971 (promoter)

Diencephalon

No

   

TATCCAGAAGGATCT

986–1000 (promoter)

  

znf800b

NA

5.1E-03

TTTCCAGAAGAGTCG

638–652 (promoter)

NA

Yes

tefa

NA

8.2E-04

CTTCCAGAAGATTCG

1289–1303 (exon2)

Not restricted

Yes

znfl2a

NA

9.9E-02

TTTCTAGCTCTTTCT

827–841 (promoter)

Blood

No ortholog

  1. The 19 TFs up-regulated during the misfolded myosin response with identified Hsf1 binding sites. Position of the potential Hsf1 binding site (p values are indicated) relative to the transcriptional start site is indicated with a reference to promoter, exonic and intronic location in parentheses. Data from RNAseq (clusters obtained by fuzzy mean clustering), expression patterns observed at 24 hpf [43], as well as HSF1 occupancy from human orthologs obtained from ChIP are indicated, if available. NA not available