TY - JOUR AU - Beroukhim, R. AU - Mermel, C. H. AU - Porter, D. AU - Wei, G. AU - Raychaudhuri, S. AU - Donovan, J. PY - 2010 DA - 2010// TI - The landscape of somatic copy-number alteration across human cancers JO - Nature. VL - 463 UR - https://doi.org/10.1038/nature08822 DO - 10.1038/nature08822 ID - Beroukhim2010 ER - TY - JOUR AU - Liu, L. AU - Lassam, N. J. AU - Slingerland, J. M. AU - Bailey, D. AU - Cole, D. AU - Jenkins, R. PY - 1995 DA - 1995// TI - Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma JO - Oncogene. VL - 11 ID - Liu1995 ER - TY - JOUR AU - Hussussian, C. J. AU - Struewing, J. P. AU - Goldstein, A. M. AU - Higgins, P. A. AU - Ally, D. S. AU - Sheahan, M. D. PY - 1994 DA - 1994// TI - Germline p16 mutations in familial melanoma JO - Nat Genet. VL - 8 UR - https://doi.org/10.1038/ng0994-15 DO - 10.1038/ng0994-15 ID - Hussussian1994 ER - TY - JOUR AU - Kannengiesser, C. AU - Brookes, S. AU - Arroyo, A. G. AU - Pham, D. AU - Bombled, J. AU - Barrois, M. PY - 2009 DA - 2009// TI - Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients JO - Hum Mutat. VL - 30 UR - https://doi.org/10.1002/humu.20845 DO - 10.1002/humu.20845 ID - Kannengiesser2009 ER - TY - JOUR AU - Chen, S. AU - Sanjana, N. E. AU - Zheng, K. AU - Shalem, O. AU - Lee, K. AU - Shi, X. PY - 2015 DA - 2015// TI - Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis JO - Cell. VL - 160 UR - https://doi.org/10.1016/j.cell.2015.02.038 DO - 10.1016/j.cell.2015.02.038 ID - Chen2015 ER - TY - JOUR AU - Merlo, A. AU - Herman, J. G. AU - Mao, L. AU - Lee, D. J. AU - Gabrielson, E. AU - Burger, P. C. PY - 1995 DA - 1995// TI - 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers JO - Nat Med. VL - 1 UR - https://doi.org/10.1038/nm0795-686 DO - 10.1038/nm0795-686 ID - Merlo1995 ER - TY - JOUR AU - Serrano, J. AU - Goebel, S. U. AU - Peghini, P. L. AU - Lubensky, I. A. AU - Gibril, F. AU - Jensen, R. T. PY - 2000 DA - 2000// TI - Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas JO - J Clin Endocrinol Metab. VL - 85 UR - https://doi.org/10.1210/jcem.85.11.6970 DO - 10.1210/jcem.85.11.6970 ID - Serrano2000 ER - TY - JOUR AU - Herman, J. G. AU - Merlo, A. AU - Mao, L. AU - Lapidus, R. G. AU - Issa, J. P. J. AU - Davidson, N. E. PY - 1995 DA - 1995// TI - Inactivation of the Cdkn2/P16/Mts1 gene is frequently associated with aberrant DNA methylation in all common human cancers JO - Cancer Res. VL - 55 ID - Herman1995 ER - TY - JOUR AU - Gonzalez-Zulueta, M. AU - Bender, C. M. AU - Yang, A. S. AU - Nguyen, T. AU - Beart, R. W. AU - Tornout, J. M. PY - 1995 DA - 1995// TI - Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing JO - Cancer Res. VL - 55 ID - Gonzalez-Zulueta1995 ER - TY - JOUR AU - Kresty, L. A. AU - Mallery, S. R. AU - Knobloch, T. J. AU - Song, H. J. AU - Lloyd, M. AU - Casto, B. C. PY - 2002 DA - 2002// TI - Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia JO - Cancer Res. VL - 62 ID - Kresty2002 ER - TY - JOUR AU - Sun, Y. AU - Deng, D. J. AU - You, W. C. AU - Bai, H. AU - Zhang, L. AU - Zhou, J. PY - 2004 DA - 2004// TI - Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study JO - Clin Cancer Res. VL - 10 UR - https://doi.org/10.1158/1078-0432.CCR-03-0622 DO - 10.1158/1078-0432.CCR-03-0622 ID - Sun2004 ER - TY - JOUR AU - Belinsky, S. A. AU - Liechty, K. C. AU - Gentry, F. D. AU - Wolf, H. J. AU - Rogers, J. AU - Vu, K. PY - 2006 DA - 2006// TI - Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort JO - Cancer Res. VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-3408 DO - 10.1158/0008-5472.CAN-05-3408 ID - Belinsky2006 ER - TY - JOUR AU - Luo, D. Y. AU - Zhang, B. Z. AU - Lv, L. B. AU - Xiang, S. Y. AU - Liu, Y. H. AU - Ji, J. F. PY - 2006 DA - 2006// TI - Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas JO - Lab Investig. VL - 86 ID - Luo2006 ER - TY - JOUR AU - Cao, J. AU - Zhou, J. AU - Gao, Y. AU - Gu, L. AU - Meng, H. AU - Liu, H. PY - 2009 DA - 2009// TI - Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study JO - Clin Cancer Res. VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-09-0580 DO - 10.1158/1078-0432.CCR-09-0580 ID - Cao2009 ER - TY - JOUR AU - Liu, H. W. AU - Liu, X. W. AU - Dong, G. Y. AU - Zhou, J. AU - Liu, Y. AU - Gao, Y. PY - 2015 DA - 2015// TI - P16 methylation as an early predictor for cancer development from oral epithelial dysplasia: a double-blind multicentre prospective study JO - EBioMedicine. VL - 2 UR - https://doi.org/10.1016/j.ebiom.2015.03.015 DO - 10.1016/j.ebiom.2015.03.015 ID - Liu2015 ER - TY - JOUR AU - Yu, D. H. AU - Waterland, R. A. AU - Zhang, P. AU - Schady, D. AU - Chen, M. H. AU - Guan, Y. PY - 2014 DA - 2014// TI - Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice JO - J Clin Invest. VL - 124 UR - https://doi.org/10.1172/JCI76507 DO - 10.1172/JCI76507 ID - Yu2014 ER - TY - JOUR AU - Hinshelwood, R. A. AU - Melki, J. R. AU - Huschtscha, L. I. AU - Paul, C. AU - Song, J. Z. AU - Stirzaker, C. PY - 2009 DA - 2009// TI - Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning JO - Hum Mol Genet. VL - 18 UR - https://doi.org/10.1093/hmg/ddp251 DO - 10.1093/hmg/ddp251 ID - Hinshelwood2009 ER - TY - JOUR AU - Maeder, M. L. AU - Angstman, J. F. AU - Richardson, M. E. AU - Linder, S. J. AU - Cascio, V. M. AU - Tsai, S. Q. PY - 2013 DA - 2013// TI - Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins JO - Nat Biotechnol. VL - 31 UR - https://doi.org/10.1038/nbt.2726 DO - 10.1038/nbt.2726 ID - Maeder2013 ER - TY - JOUR AU - Chen, H. AU - Kazemier, H. G. AU - Groote, M. L. AU - Ruiters, M. H. AU - Xu, G. L. AU - Rots, M. G. PY - 2014 DA - 2014// TI - Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter JO - Nucleic Acids Res. VL - 42 UR - https://doi.org/10.1093/nar/gkt1019 DO - 10.1093/nar/gkt1019 ID - Chen2014 ER - TY - JOUR AU - Rivenbark, A. G. AU - Stolzenburg, S. AU - Beltran, A. S. AU - Yuan, X. AU - Rots, M. G. AU - Strahl, B. D. PY - 2012 DA - 2012// TI - Epigenetic reprogramming of cancer cells via targeted DNA methylation JO - Epigenetics. VL - 7 UR - https://doi.org/10.4161/epi.19507 DO - 10.4161/epi.19507 ID - Rivenbark2012 ER - TY - JOUR AU - Zhang, B. AU - Xiang, S. AU - Zhong, Q. AU - Yin, Y. AU - Gu, L. AU - Deng, D. PY - 2012 DA - 2012// TI - The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors JO - Hum Gene Ther. VL - 23 UR - https://doi.org/10.1089/hum.2012.070 DO - 10.1089/hum.2012.070 ID - Zhang2012 ER - TY - JOUR AU - Bernstein, D. L. AU - Lay, J. E. AU - Ruano, E. G. AU - Kaestner, K. H. PY - 2015 DA - 2015// TI - TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts JO - J Clin Invest. VL - 125 UR - https://doi.org/10.1172/JCI77321 DO - 10.1172/JCI77321 ID - Bernstein2015 ER - TY - JOUR AU - Serrano, M. AU - Hannon, G. J. AU - Beach, D. PY - 1993 DA - 1993// TI - A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 JO - Nature. VL - 366 UR - https://doi.org/10.1038/366704a0 DO - 10.1038/366704a0 ID - Serrano1993 ER - TY - JOUR AU - McDermott, K. M. AU - Zhang, J. AU - Holst, C. R. AU - Kozakiewicz, B. K. AU - Singla, V. AU - Tlsty, T. D. PY - 2006 DA - 2006// TI - p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells JO - PLoS Biol. VL - 4 UR - https://doi.org/10.1371/journal.pbio.0040051 DO - 10.1371/journal.pbio.0040051 ID - McDermott2006 ER - TY - JOUR AU - Chien, Y. AU - Scuoppo, C. AU - Wang, X. AU - Fang, X. AU - Balgley, B. AU - Bolden, J. E. PY - 2011 DA - 2011// TI - Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity JO - Genes Dev. VL - 25 UR - https://doi.org/10.1101/gad.17276711 DO - 10.1101/gad.17276711 ID - Chien2011 ER - TY - JOUR AU - Ghiorzo, P. AU - Mantelli, M. AU - Gargiulo, S. AU - Gramigni, C. AU - Pastorino, L. AU - Banelli, B. PY - 2004 DA - 2004// TI - Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression JO - Hum Pathol. VL - 35 UR - https://doi.org/10.1016/j.humpath.2004.02.017 DO - 10.1016/j.humpath.2004.02.017 ID - Ghiorzo2004 ER - TY - JOUR AU - Song, Z. B. AU - Ni, J. S. AU - Wu, P. AU - Bao, Y. L. AU - Liu, T. AU - Li, M. PY - 2015 DA - 2015// TI - Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression JO - Cell Death Dis. VL - 6 UR - https://doi.org/10.1038/cddis.2015.61 DO - 10.1038/cddis.2015.61 ID - Song2015 ER - TY - JOUR AU - Li, H. L. AU - Han, L. AU - Chen, H. R. AU - Meng, F. AU - Liu, Q. H. AU - Pan, Z. Q. PY - 2015 DA - 2015// TI - PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription JO - Oncotarget. VL - 6 UR - https://doi.org/10.18632/oncotarget.4011 DO - 10.18632/oncotarget.4011 ID - Li2015 ER - TY - JOUR AU - Zhang, Y. AU - Huang, H. AU - Zhou, H. AU - Du, T. AU - Zeng, L. AU - Cao, Y. PY - 2014 DA - 2014// TI - Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer JO - Cancer. VL - 120 UR - https://doi.org/10.1002/cncr.28796 DO - 10.1002/cncr.28796 ID - Zhang2014 ER - TY - JOUR AU - Liu, Z. J. AU - Zhang, J. AU - Gao, Y. H. AU - Pei, L. R. AU - Zhou, J. AU - Gu, L. K. PY - 2014 DA - 2014// TI - Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis JO - Clin Cancer Res. VL - 20 UR - https://doi.org/10.1158/1078-0432.CCR-13-3380 DO - 10.1158/1078-0432.CCR-13-3380 ID - Liu2014 ER - TY - JOUR AU - Emburgh, B. O. AU - Robertson, K. D. PY - 2011 DA - 2011// TI - Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants JO - Nucleic Acids Res. VL - 39 UR - https://doi.org/10.1093/nar/gkr116 DO - 10.1093/nar/gkr116 ID - Emburgh2011 ER - TY - JOUR AU - Xu, J. AU - Wang, Y. Y. AU - Dai, Y. J. AU - Zhang, W. AU - Zhang, W. N. AU - Xiong, S. M. PY - 2014 DA - 2014// TI - DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells JO - Proc Natl Acad Sci U S A. VL - 111 UR - https://doi.org/10.1073/pnas.1400150111 DO - 10.1073/pnas.1400150111 ID - Xu2014 ER - TY - JOUR AU - Russler-Germain, D. A. AU - Spencer, D. H. AU - Young, M. A. AU - Lamprecht, T. L. AU - Miller, C. L. AU - Fulton, R. PY - 2014 DA - 2014// TI - The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers JO - Cancer Cell. VL - 25 UR - https://doi.org/10.1016/j.ccr.2014.02.010 DO - 10.1016/j.ccr.2014.02.010 ID - Russler-Germain2014 ER - TY - JOUR AU - Deng, D. J. AU - Deng, G. R. AU - Smith, M. F. AU - Zhou, J. AU - Xin, H. J. AU - Powell, S. M. PY - 2002 DA - 2002// TI - Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography JO - Nucleic Acids Res. VL - 30 UR - https://doi.org/10.1093/nar/30.3.e13 DO - 10.1093/nar/30.3.e13 ID - Deng2002 ER - TY - JOUR AU - Herman, J. G. AU - Graff, J. R. AU - Myohanen, S. AU - Nelkin, B. D. AU - Baylin, S. PY - 1996 DA - 1996// TI - Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands JO - Proc Natl Acad Sci U S A. VL - 93 UR - https://doi.org/10.1073/pnas.93.18.9821 DO - 10.1073/pnas.93.18.9821 ID - Herman1996 ER - TY - JOUR AU - Li, Q. AU - Wang, X. AU - Lu, Z. AU - Zhang, B. AU - Guan, Z. AU - Liu, Z. PY - 2010 DA - 2010// TI - Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus JO - PLoS One. VL - 5 UR - https://doi.org/10.1371/journal.pone.0013732 DO - 10.1371/journal.pone.0013732 ID - Li2010 ER - TY - JOUR AU - Langmead, B. AU - Trapnell, C. AU - Pop, M. AU - Salzberg, S. L. PY - 2009 DA - 2009// TI - Ultrafast and memory-efficient alignment of short DNA sequences to the human genome JO - Genome Biol. VL - 10 UR - https://doi.org/10.1186/gb-2009-10-3-r25 DO - 10.1186/gb-2009-10-3-r25 ID - Langmead2009 ER - TY - JOUR AU - Zhang, Y. AU - Liu, T. AU - Meyer, C. A. AU - Eeckhoute, J. AU - Johnson, D. S. AU - Bernstein, B. E. PY - 2008 DA - 2008// TI - Model-based Analysis of ChIP-Seq (MACS) JO - Genome Biol. VL - 9 UR - https://doi.org/10.1186/gb-2008-9-9-r137 DO - 10.1186/gb-2008-9-9-r137 ID - Zhang2008 ER - TY - JOUR AU - Machanick, P. AU - Bailey, T. L. PY - 2011 DA - 2011// TI - MEME-ChIP: motif analysis of large DNA datasets JO - Bioinformatics. VL - 2712 UR - https://doi.org/10.1093/bioinformatics/btr189 DO - 10.1093/bioinformatics/btr189 ID - Machanick2011 ER - TY - JOUR AU - Kijima-Suda, I. AU - Miyamoto, Y. AU - Toyoshima, S. AU - Itoh, M. AU - Osawa, T. PY - 1986 DA - 1986// TI - Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity JO - Cancer Res. VL - 46 ID - Kijima-Suda1986 ER -