Skip to main content

Advertisement

Table 2 Top 2 annotation clusters enriched in proestrus versus males

From: The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1

Cluster enrichment score Term Count p-value Fold enrichment
Cluster #1: 1.45 Negative regulation of transcription, DNA-dependent 5 5.41E−03 6.55
  Negative regulation of RNA metabolic process 5 5.71E−03 6.45
  Negative regulation of transcription 5 1.20E−02 5.20
  Negative regulation of transcription from RNA polymerase II promoter 4 1.51E−02 7.22
  Negative regulation of gene expression 5 1.61E−02 4.77
  Negative regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process 5 1.73E−02 4.68
  Negative regulation of nitrogen compound metabolic process 5 1.82E−02 4.60
  Negative regulation of macromolecule biosynthetic process 5 2.09E−02 4.42
  Negative regulation of cellular biosynthetic process 5 2.23E−02 4.33
  Negative regulation of biosynthetic process 5 2.41E−02 4.23
  Negative regulation of macromolecule metabolic process 5 5.54E−02 3.25
  Regulation of transcription from RNA polymerase II promoter 4 1.48E−01 2.85
  Transcription 4 2.03E−01 2.45
  Regulation of transcription, DNA-dependent 5 2.23E−01 1.96
  Regulation of RNA metabolic process 5 2.40E−01 1.90
  Regulation of transcription 6 2.41E−01 1.70
Cluster #2: 0.57 Regulation of growth 3 1.57E−01 4.04
  Negative regulation of apoptosis 3 1.78E−01 3.74
  Negative regulation of programmed cell death 3 1.81E−01 3.70
  Negative regulation of cell death 3 1.82E−01 3.68
  Regulation of apoptosis 3 4.74E−01 1.82
  Regulation of programmed cell death 3 4.81E−01 1.80
  Regulation of cell death 3 4.83E−01 1.79