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Fig. 5 | Genome Biology

Fig. 5

From: The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1

Fig. 5

Egr1 binds to synapse-related genes in a sex-specific and estrus cycle-specific manner. a The majority of differential Egr1 binding was observed in proestrus when compared to either males (pink circle) or diestrus females (green circle). b, c treemap representation of Cellular Compartment terms from the Gene Ontology database, showing a marked enrichment of receptors complexes, synapse, and zones of cell–cell communication localizations in proestrus when compared to males (b) or diestrus (c). The size of each rectangle is proportional to the -log10 of the p-value (the bigger the rectangle, the more significant the enrichment). df The enrichment analysis of pathways from the Kyoto Encyclopedia of Genes and Genomes on the nearest genes to a differential Egr1 binding locations reveals an alteration of signal transduction pathways between males and females in proestrus (d) and diestrus (e), as well as within females (f)

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