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Fig. 4 | Genome Biology

Fig. 4

From: The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1

Fig. 4

Estrous cycle-dependent transcriptomic regulation exceeds sex differences and primarily targets synaptic function. A gene clustering analysis identified nine distinct profiles of gene regulation between males (left side), proestrus (center), and diestrus females (right side). At the top left corner of each plot is detailed the total number of genes as well as the percentage of all differentially expressed genes represented in the cluster. In each cluster, the enrichment in Biological Processes from the Gene Ontology (GO) database was analyzed for the differentially expressed genes represented in the cluster. The first four hits (if four or more hits were found) ranked by p-value are depicted on the right of each plot and highlight the enrichment of synapse-related genes in proestrus females from clusters 1 and 2, translation processes in diestrus females from clusters 3 and 4, and interaction with the extracellular matrix from cluster 6. The full list of enriched GO terms can be found in Additional file 10: Table S5

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