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Fig. 1 | Genome Biology

Fig. 1

From: The societal opportunities and challenges of genome editing

Fig. 1

Pathways of repair after nuclease cleavage. In a cell with many chromosomes, a unique site on one chromosome is targeted for cleavage by a programmable nuclease (redlightning bolt’). Cells repair the break either by non-homologous end joining (NHEJ), which can leave small insertions or deletions (indels), or homology-dependent repair (HDR) using a template supplied by the experimenter. Although mitotic chromosomes are illustrated here, it is unlikely that these processes occur specifically in mitosis

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