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Table 3 Infectivity of parasite strains in Anopheles stephensi

From: Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

Parasite line

Midgut sporozoites/mosquito

Salivary gland sporozoites/mosquito

Salivary gland sporozoites/midgut sporozoites

Number of infected mosquitoes analysed

WT

111,000

21,000

0.19

30

SpZFN

84,000

12,000

0.14

18

LsZFN

157,000

29,000

0.18

22

Sp2ZFN

50,000

2500

0.05

30

Ls2ZFN

181,000

22,000

0.12

30

Uis4ZFN

5300

1700

0.32

14

TrapZFN

55,000

25,000

0.46

11

SpZFN SI 2

17,000

8300

0.49

30