Table 2 Protection of immunised mice against P. berghei ANKA WT challenge
Parasite line | Sporozoite dose i.v. for immunisation | Number of boosts | Mice positive after WT challenge | Prepatency after challenge (days) |
|---|---|---|---|---|
SpZFN | 10,000 | 2 | 0/4 | NA |
SpZFN | 25,000 | 2 | 0/18 | NA |
Sp2ZFN | 25,000 | 2 | 2/4 | 5.5 |
Sp2ZFN | 10,000 | 2 | 1/4 | 7 |
Ls2ZFN | 25,000 | 2 | 0/7 | NA |
Ls2ZFN | 250,000 | 0 | 4/4 | 5.5 |