Network analysis of gene essentiality in functional genomics experiments

Table 1 Confounding factors for NEST prediction performance

Covariate	Coefficient	Standard error	Z-score	P value
NEST	0.02329	0.001748	13.32	1.72e-40
Degree	0.00415	0.000846	4.91	9.33e-07
Expression	0.12937	0.054223	2.39	1.70e-02
A. K562
NEST	0.03494	0.00505	6.91	4.73e-12
Degree	0.00608	0.00146	4.16	3.13e-05
Expression	0.33873	0.16595	2.04	4.12e-02
B. HL60
NEST	0.07296	0.02483	2.94	0.00329
Degree	0.00792	0.00357	2.22	0.02647
Expression	1.12266	0.48343	2.32	0.02022
C. A375

The prediction power of NEST score on gene essentiality decided by CRISPR screen is tested through logistic regression with gene network degree and gene expression as covariates. The Logit Z-score is defined as Coef/Stderr. The P value is calculated by Ward test. The result is shown for (A) K562, (B) HL60, and (C) A375

ISSN: 1474-760X