Fig. 5
From: Network analysis of gene essentiality in functional genomics experiments
Cytokine receptor interaction network for GBM survival. For all members in KEGG pathway Cytokine Cytokine-Receptor Interaction, we selected the genes indicating death risk with FDR threshold 0.05. The pathway members are colored by their gene family categories, including Chemokine, Tumor Necrosis Factor (TNF), Interleukin, and Receptor Tyrosine Kinase (RTK). A diamond shape indicates the gene to be drug targetable in Drug Bank. The node size is proportional to the NEST score averaged among all GBM patients. Stars are used to label known oncogenes annotated by Vogelstein et al. The directed edge indicates a cytokine-to-receptor relation in KEGG, and undirected edge indicates an experimental protein interaction curated by STRING. The thickness of each edge indicates the interaction confidence