HiFive: a tool suite for easy and efficient HiC and 5C data analysis

Table 1 A comparison of HiC Analysis software algorithms and features

Method	Normalization algorithm	Can account for distance	Fend-level resolution	Parallelizable
HiFive	Matrix balancing	X	X	X
	Binning	X	X	X
	Probability	X	X	X
HiCPipe	Binning		X	X
HiCNorm	Poisson regression
HiCLib	Matrix balancing		X
HiTC^a	Poisson regression
	Matrix balancing		X
HOMER	Read coverage	X		X
Hi-Corrector	Matrix balancing		X	X

^aThis method is an R-based implementation of HiCLib’s and HiCNorm’s normalization approaches

ISSN: 1474-760X