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Fig. 3 | Genome Biology

Fig. 3

From: A transient ischemic environment induces reversible compaction of chromatin

Fig. 3

Quantification of chromatin compaction through binning. The influence of OND on the nuclear distribution and accessibility of chromatin was characterized by analysis of joint localization maps generated by SMLM. a The median and range of densities of single molecule localizations, calculated over the entire nucleus and for a minimum of nine cells, for untreated, OND exposed and recovering cells. A binning approach, outlined in (b), was then used to characterize the extent of chromatin compaction as cells transition from normal conditions through OND and in recovery from OND (c), with the median and range of the distribution shown above each histogram. The proportion of bins containing ≥ 25 localizations is presented as a bar on the right of each panel. d As the distributions of histograms of binned data differ significantly between time points, the skewness (deviation from the mean) was calculated for all of the images. UT untreated

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