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Table 1 Significant base counts in functional gRNAs

From: WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system

Mono- or dinucleoside count

Enrichment ratioa

P valueb

A

1.39

9.3E–18

U

0.89

1.9E–03

G

0.92

6.2E–03

C

0.95

5.5E–02

GG

0.64

2.3E–11

AG

1.43

1.3E–09

CA

1.38

6.7E–09

AC

1.47

1.2E–08

UU

0.59

7.5E–08

UA

1.84

1.1E–07

GC

0.77

3.2E–06

  1. aThe enrichment ratio was determined by comparing the average nucleoside counts of functional gRNAs to that of non-functional gRNAs. bThe P values were calculated with Student’s t-test
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Genome Biology

ISSN: 1474-760X

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