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Fig. 2 | Genome Biology

Fig. 2

From: gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens

Fig. 2

gespeR predicts siRNA phenotypes with significantly higher accuracy than in silico pooling (ISP) and haystack across all pathogens. Mutual concordance is evaluated between predicted and measured reagent-specific phenotypes (RSPs) for the same siRNAs. *Significantly better than second best method (Wilcoxon rank sum test, p < 0.05). a Phenotypes for 1871 validation screen siRNAs from Ambion were predicted in a blind test prior to experiments and evaluated against eventually measured RSPs. b Subsetting seven data points for the kinome-wide data set, RSPs were repeatedly predicted for a training set and evaluated against a disjoint test set

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