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Fig. 3 | Genome Biology

Fig. 3

From: Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells

Fig. 3

Topologically associating domains are similar between MCF-10A and MCF-7. a TADs are similar between MCF-10A and MCF-7 genomes. An example heatmap of a portion of MCF-10A chr14 at 40 kb resolution, where the upper part of the heatmap shows the MCF-7 TADs and the bottom part shows the MCF-10A TADs. b Venn diagram showing that the majority (~85 %) of all the TAD boundaries between MCF7 and MCF10A are conserved. c Heatmap showing an example of a differential TAD between MCF-10A (blue) and MCF-7 (red) on chr21 (chr21:16647759–30544567). The black dots represent the overlapping boundaries that are present in both cell lines, and the red dot denotes the MCF7-specific TAD boundary. d The percentage of unchanged (grey), MCF7 down-regulated (blue) and MCF7 up-regulated (red) genes located at each TAD boundary category. e Frequency plots of factors enriched at MCF- 7 TAD boundaries per 25 kb for ±1 Mb of every MCF-7 TAD boundary

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Genome Biology

ISSN: 1474-760X

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