Fig. 4

Quality control of genotype data for AE analysis. a Median percentage of het-SNPs where RNA-seq reads from both alleles are observed across all tissues for GTEx samples, genotyped with different platforms: exome-seq (yellow), Illumina OMNI 5 M SNP array (blue), and sites imputed from OMNI 5 M genotype array (red). Grey arrowheads indicate outlier individuals that are likely to have lower genotype quality. b Total het-SNP read count versus the read count of the lesser-covered allele for an individual Geuvadis sample. Sites flagged as putative genotyping errors are marked in red, with RNA-seq data not rendering support for heterozygosity