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Fig. 5 | Genome Biology

Fig. 5

From: An ensemble approach to accurately detect somatic mutations using SomaticSeq

Fig. 5

Obtaining the ground truth for the in silico tumor–normal data. In the NA12878 and NS12911 mixture, there are a total of 746,280 virtual somatic SNVs and 64,399 virtual somatic indels. A total of 2.2 billion high-confidence sites are interrogated (the remaining are ignored). During our analyses, a somatic mutation rate of one out of a million was enforced to represent a realistic prior probability of somatic mutations

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