Table 3 Top somatically mutated genes in cancer susceptibility regions
From: Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation
Cancer subtype | First | Second | Third | Fourth | Fifth |
|---|---|---|---|---|---|
Bladder | FGFR3 (14.939) | EPG5 (3.049) | TP63 (2.744) | GIGYF2 (2.439) | MECOM (2.439) |
Breast | MAP3K1 (6.285) | SYNE1 (4.773) | BRCA2 (2.784) | ZFHX4 (2.705) | NOTCH2 (1.591) |
Cervical | COL11A2 (10.256) | MED1 (10.256) | EHMT2 (7.692) | CDK12 (7.692) | ABCF1 (5.128) |
Colon | HYDIN (11.161) | RYR3 (9.821) | MAP3K4 (7.143) | IGF2R (6.696) | MYO1B (5.804) |
Endometrial | ACACA (7.661) | SYNRG (2.823) | TADA2A (2.419) | DUSP14 (1.613) | C17orf78 (1.210) |
Glioma (glioblastoma) | EGFR (20.235) | PLEKHG4B (1.760) | CDKN2A (1.466) | HELZ2 (1.466) | SLC6A19 (1.173) |
Glioma (low grade) | EGFR (5.882) | SLC6A3 (2.076) | PLEKHG4B (1.384) | SLC6A19 (1.384) | KMT2A (1.384) |
Kidney (chromophobe) | ORAOV1 (1.515) | PPFIA1 (1.515) | SHANK2 (1.515) | NA (−.---) | NA (−.---) |
Kidney (clear cell) | ITPR2 (1.724) | PPFIA1 (1.149) | PRKCE (0.766) | ZEB2 (0.766) | EPAS1 (0.575) |
Kidney (papillary) | ITPR2 (3.571) | PPFIA1 (2.381) | PRKCE (1.190) | ZEB2 (1.190) | FGF3 (1.190) |
Liver | PIK3CD (1.938) | KIF1B (1.938) | CASZ1 (1.550) | MYO1B (1.550) | CLDN8 (1.550) |
Lung (adenoma) | NOTCH4 (6.509) | TNXB (5.178) | MDC1 (3.402) | PLEKHG4B (3.254) | ZBED9 (3.254) |
Lung (small cell) | ZBED9 (7.042) | SLC17A2 (5.634) | BRD9 (4.225) | SLC6A19 (4.225) | HIST1H2AA (4.225) |
Lung (squamous) | TNXB (5.618) | SLC6A3 (5.056) | LRRC16A (3.933) | BTN2A2 (3.933) | ZBED9 (3.933) |
Multiple myeloma | LTB (1.951) | NEU1 (1.951) | DNAH11 (1.951) | TNXB (1.463) | CACNA1I (1.463) |
Ovarian (serous) | CPAMD8 (1.899) | UNC13A (1.266) | MAST3 (1.266) | HOXD10 (0.949) | C10orf113 (0.949) |
Ovarian (small) | JAK3 (8.333) | NA (−.---) | NA (−.---) | NA (−.---) | NA (−.---) |
Prostate | SPOP (7.877) | SYNE1 (3.425) | RYR1 (2.397) | TNXB (2.055) | APOB (1.712) |
Skin | SORCS3 (14.082) | CDKN2A (13.878) | TRIOBP (11.224) | ANKRD11 (8.571) | AOX1 (8.367) |
Stomach | ZBTB20 (7.273) | MROH2B (5.455) | C6 (4.545) | DRD3 (2.727) | OXCT1 (2.727) |
Thyroid | TNS1 (0.748) | TDRD7 (0.499) | TBC1D2 (0.499) | MBIP (0.499) | NKX2-1 (0.499) |