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Table 2 Top somatically mutated genes by cancer subtype

From: Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation

Cancer subtype Samples Most mutated (percentage samples) GWAS locus
Bladder 328 PIK3CA (20.43) No
Breast 1257 TP53 (33.73) No
Cervical 39 TTN (51.28) No
Colon 224 APC (75.00) No
Endometrial 248 PTEN (64.92) No
Glioma 289 IDH1 (76.12) No
Kidney (chrom) 66 MUC4 (66.67) No
Kidney (clear) 522 VHL (46.55) No
Kidney (pap) 168 TTN (25.00) No
Liver 258 TP53 (32.17) No
Lung (adeno) 676 TP53 (47.34) No
Lung (small) 71 TP53 (87.32) No
Lung (squamous) 178 TP53 (90.45) No
Multiple Myeloma 205 ADAM6 (30.73) No
Ovarian (serous) 316 TP53 (94.62) No
Ovarian (small) 12 SMARCA4 (91.67) No
Prostate 584 ERG (29.87) No
Skin 490 TTN (67.14) No
Stomach 220 TTN (56.36) No
Thyroid 401 BRAF (61.35) No