Table 2 Top somatically mutated genes by cancer subtype
From: Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation
Cancer subtype | Samples | Most mutated (percentage samples) | GWAS locus |
|---|---|---|---|
Bladder | 328 | PIK3CA (20.43) | No |
Breast | 1257 | TP53 (33.73) | No |
Cervical | 39 | TTN (51.28) | No |
Colon | 224 | APC (75.00) | No |
Endometrial | 248 | PTEN (64.92) | No |
Glioma | 289 | IDH1 (76.12) | No |
Kidney (chrom) | 66 | MUC4 (66.67) | No |
Kidney (clear) | 522 | VHL (46.55) | No |
Kidney (pap) | 168 | TTN (25.00) | No |
Liver | 258 | TP53 (32.17) | No |
Lung (adeno) | 676 | TP53 (47.34) | No |
Lung (small) | 71 | TP53 (87.32) | No |
Lung (squamous) | 178 | TP53 (90.45) | No |
Multiple Myeloma | 205 | ADAM6 (30.73) | No |
Ovarian (serous) | 316 | TP53 (94.62) | No |
Ovarian (small) | 12 | SMARCA4 (91.67) | No |
Prostate | 584 | ERG (29.87) | No |
Skin | 490 | TTN (67.14) | No |
Stomach | 220 | TTN (56.36) | No |
Thyroid | 401 | BRAF (61.35) | No |