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Table 1 Number of included cancer susceptibility regions and nearby genes for each cancer type investigated

From: Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation

Cancer subtype GWAS loci LD genes Nearby genes
Bladder 12 103 264
Breast 80 702 1324
Cervical 7 148 290
Colon 25 215 421
Endometrial 1 1 18
Glioma 9 90 212
Kidney 5 12 48
Liver 7 89 195
Lung 10 257 350
Multiple myeloma 5 129 219
Ovarian 10 119 213
Prostate 71 697 1583
Skin 14 311 493
Stomach 2 12 24
Thyroid 5 15 40
Total 263 2190 4103
  1. All cancer susceptibility regions have a published p value less than 5 × 10−8, are independent of each other, are associated with cancer in European populations, and were discovered prior to 25 August 2014. Linkage disequilibrium (LD) genes are those within the LD block of the susceptibility variant. Nearby genes are defined as those within the LD block of the susceptibility variant or within 500 kb of the LD block. For the genes, the total is for all unique genes and excludes duplicates across cancer types