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Fig. 9 | Genome Biology

Fig. 9

From: Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength

Fig. 9

Model describing role of 5′ splice site strength in determining constitutive and alternative splicing regulated by PRPF8. In conditions of abundant PRPF8, there is competition between strong and weak 5′ splice sites to determine splice site choice and spliceosome assembly is proficient. When PRPF8 is limited, this causes a reduction in spliceosome assembly, such that strong 5′ splice sites are favored over weak 5′ splice sites, resulting in altered splicing patterns in a subset of transcripts

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Genome Biology

ISSN: 1474-760X

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