Fig. 4

Common disease linked SNPs are correlated with senDMP signature. a For each of the senDMPs Pearson’s correlation coefficient was calculated for each SNP (in this figure rs10811661). We then compared the directionality of senDMPs (DS-EP – in this example the agree sites have been used) to the correlation with genotype (risk allele–alternative allele) and calculated a chi-squared. b A density plot of the chi-squared statistic for all (2,862) GWAS SNPs present on the genotype array. Highlighted in colour are those SNPs associated with the p16 locus of which two show significant directionality with our senDMPs across the three groups of senDMPs. These are plotted left to right: blue – experiment 1 only, green – experiment 2 only, and purple – agree. c A density plot of the chi-squared statistic for all GWAS SNPs measuring the association with senDMP signature (blue – experiment 1 only, green – experiment 2 only, and purple – agree) and 100 random shuffled signatures (black). d Venn diagram illustrating the traits associated with the SNPs which correlated with the senDMP signatures (blue – experiment 1 only, green – experiment 2 only, and purple – agree)