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Fig. 1 | Genome Biology

Fig. 1

From: Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution

Fig. 1

a Schematic representation of the differences between Micro-C and Hi-C contacts. Top: snapshot from a physical simulation of the yeast chromosomes as a brush of polymers (white beads) tethered by their centromeres (yellow spheres). The large structure on the right represents the nucleolus (see also [6]). Chromosomes 3 and 11 are highlighted in red and cyan. Each bead represents three nucleosomes. Bottom: expanded view of four nucleosomes (purple circles). Contacts, from frequent to rare, are highlighted on both representations in red, orange and yellow. b Models of the chromosomal fiber with 167-bp nucleosomal repeat length (built using the three angle model described in Riposo and Mozziconacci [9]). c Number of contacts in parts per million (ppm) obtained through a Micro-C experiment at various genomic distances (schematic representation of the results presented in Figure S3 of Hsieh et al. [5]). The first bump corresponds to contacts between nucleosome n and n + 1, and the second bump to contacts between n and n + 2. Only reads in the same orientation were used to avoid self-ligation artifacts

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