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Fig. 5 | Genome Biology

Fig. 5

From: Extensive identification and analysis of conserved small ORFs in animals

Fig. 5

dORFs (sORFs in 3′UTRs) are not explained by stop-codon read-through or alternative terminal exons. Results are shown for H. sapiens. a The step in the phastCons conservation track near the stop codon of the upstream CDS is only slightly less pronounced than for CDS without downstream conserved sORF. b The dORFs are closer to the CDS than control sORFs, but they are not more often in the same frame (c), and they have a similarly high number of intervening in-frame stop codons (d). e The step in the phastCons conservation track near start of predicted dORFs start is more pronounced than in other dORFs. f Even before applying the overlap filter, very few predicted dORFs overlap with annotated coding exons. ***P <0.001; **P <0.01; *P <0.05; n.s. not significant. Mann-Whitney tests in a, d, and e, Kolmogorov-Smirnov test in b, Χ2 test in c, Binomial test in f

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