Fig. 14
From: Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data
DNase data can predict A/B compartments revealed by Hi-C. The figure displays data on all of chromosome 14 at 100-kb resolution. a The first eigenvector of the HiC-EBV-2014 dataset. b The smoothed first eigenvector of the correlation matrix of the binned DNase-EBV dataset after median centering. c Average DNase signal across samples after binning and median subtraction. The sign of the signal was reversed for display purposes. d The first eigenvector of the HiC-IMR90-2014 dataset. e The smoothed first eigenvector of the correlation matrix of the binned HiC-DNase-IMR90 dataset after median centering. f Average DNase signal across samples after binning and median subtraction. The sign of the signal was reversed for display purposes. Both the average signal and correlation eigenvector are highly predictive of the Hi-C compartments for both cell types