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Fig. 4 | Genome Biology

Fig. 4

From: Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions

Fig. 4

1xCTSes and 2xCTSes are associated with different epigenetic landscapes in both BORIS-positive (K562) and BORIS-negative (GM12878) cells. a Gene tracks show the association of CTCF and BORIS bound regions in K562 cells with multiple ENCODE ChIP-seq data. The tracks are labeled with the names of molecules against which antibodies were directed for ChIP-seq. The gray frames highlight CTCF-only, CTCF&BORIS and BORIS-only bound regions. b Average tag density (tags/10 million) of multiple factors mapped by ChIP-seq in K562 cells (ENCODE data) across BORIS-only (blue), CTCF-only (red) and CTCF&BORIS (purple) bound regions mapped in K562 cells. The data were normalized to the number of mapped reads and binding regions. The names of factors used in ChIP-seq are labeled on the top of each plot. RNAPII RNA polymerase II. c Heatmap demonstrates the difference between 1xCTSes and 2xCTSes with respect to the enrichment of RNAPII, CAGEs, H3K4me3, H2AZ, H3K27ac, ZNF143, and SMC3 ChIP-seq tag density at two types of CTCF binding classes in BORIS-negative cells (GM12878)

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