Fig. 3
RNA-seq analyses detect graded changes in gene expression in P10 heterozygous Crx mutant retinas. a-c Gene expression (log2 CPM) in the indicated heterozygotes (y-axes) are compared with the WT control (C57BL/6 J, x-axes). Prototypical photoreceptor transcripts are labeled in white. White diagonal lines represent ±2 FC. d, e Venn diagrams illustrate the numbers of significantly affected genes that are shared or are uniquely changed in the indicated mutants (FC ≥ 2 or ≤ -2, FDR ≤ 0.05). f, g Analysis of the union of genes affected in heterozygous mutants (FC ≥ 2 or ≤ -2, FDR ≤ 0.05) presented as FC relative to WT control. Significance calculated by Wilcoxon rank-sum test with Bonferroni correction. Notched box whisker plot describes median and quartiles of data