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Fig. 7 | Genome Biology

Fig. 7

From: OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy

Fig. 7

Overview of the steps in the OrthoFinder algorithm for two example orthogroups of genes from three species. a The unknown orthogroups that the algorithm must recover, shown as a gene tree. b BLAST search of all genes against all genes. c Gene length and phylogenetic distance normalisation of BLAST bit scores to give the scores to be used for orthogroup inference. d Selection of putative cognate gene-pairs from normalised BLAST scores. e Construction of orthogroup graph, genes are nodes in the graph and pairs of genes are connected by an edge with edge weights given by the normalised bit score. f Clustering of genes into discrete orthogroups using MCL

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Genome Biology

ISSN: 1474-760X

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