Fig. 1

BioWardrobe overview and poising of genes in T cells. a The BioWardrobe server can be set up on a Linux or Mac computer attached to a storage array, typically within a local institutional network. Researchers can use BioWardrobe to upload data from a sequencing core or a public database and promptly receive quality control data, view the results in the browser, and perform some of the analysis without the assistance of bioinformaticians. Bioinformaticians can access the precomputed data in Wardrobe’s SQL database to perform further analysis. b The H3K4me3 average tag density profiles for the gene body in naïve T cells for genes that are expressed or silent in both naïve T helper (Thn) cells and T helper type 1 (Th1) cells and those that are induced during Thn to Th1 transition. The box plot window shows the distribution of H3K4me3 tag densities for the three gene sets within the area shaded in the plot (Silent, Expressed, Induced). Mann-Whitney-Wilcoxon (MWW) p values are shown below the box plot. Here and in most of the other figures the plot was produced in BioWardrobe, saved as an .svg and adjusted in Adobe Illustrator. TES transcription end site, TSS transcription start site