Fig. 4

Properties of RER regions in breast cancer cell lines. Analysis of mean expression (mean z score of genes with significant TCSs) levels in breast cancer cell lines for cluster 1 RER regions (a) and RER regions of clusters 2 and 3 (c). RER regions were subject to hierarchical clustering and cell lines were ordered by their overall level of expression of each RER cluster. Box plots showing mean expression (mean z score of genes with significant TCSs) of RER regions from cluster 1 (b) and clusters 2 and 3 (d) in ER+ (gray) and ER− (white) breast cancer cell lines (*p < 0.05, ***p < 0.001)