Fig. 2

Gene expression changes in tumors and normal tissue. Box plots show the distribution of mean centered z scores of gene expression in tumor samples and normal breast tissue and breast organoids [28] for genes in the RER regions at 2p24.2-p25.1 (a), 12q15-q21.33 (b) and 16p11.2 (c). Data for tumors are separated according to ER status and Wilcoxon tests were used to determine whether or not there was a significant difference between tumor and normal samples taken together