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Fig. 3 | Genome Biology

Fig. 3

From: A novel method of consensus pan-chromosome assembly and large-scale comparative analysis reveal the highly flexible pan-genome of Acinetobacter baumannii

Fig. 3

Clone-type specific RI signatures and RI insertion frequencies over time. a–c Genomic locations of RI signatures specific to clonal complexes (CCs) 1–3 and ST 25. In CC1 isolates, RI insertions are detected in the comM and/or pho loci (a). In CC2 isolates, RI insertions are found in the comM locus, and in addition the astA, or acetylT locus. A novel RI insertion (composite IS26) was identified in CC3 isolates at the acyl-CoA synthase (acylCS) locus (b). Gene annotation of the composite IS26 RI is shown to the right. Drug resistance genes (green); immediate flanking genes acylCS and a transporter protein (dark orange). A novel GI was identified in ST 25 isolates at the acetylT locus (c). Gene annotation of the 7.8 kb GI is shown to the right. Salicylate monooxygenase (blue); immediate flanking genes acetylT and mdtL (dark orange). A cumulative frequency graph showing the number of RI-positive isolates carrying single, double, or triple RI insertions collected between 1950 and 2011 (d). Isolates that represent the first occurrence of a given RI signature are labeled on the graph (numbered 1–9)

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