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Fig. 5 | Genome Biology

Fig. 5

From: CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer

Fig. 5

CoMEt results on TCGA GBM. a Two output modules from CoMEt are shown in the same style as in Fig. 4. Characters in parentheses following gene name indicate copy number aberrations: (D) is a deletion, and (A) is an amplification. b Different splice variants of CDKN2A are part of both the Rb signaling (left) and p53 signaling (right) pathways. CoMEt recovers this relationship as two separate mutually exclusive gene sets. The gene sets {RB1, CDK4} and {MDM2, TP53} have a statistically significant number of co-occurring mutations (P=6×10−21, dotted orange line), which is much more significant than the co-occurrence between pairs of genes in these sets (dotted red lines with corresponding P-values)

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