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Fig. 3 | Genome Biology

Fig. 3

From: FOXM1 binds directly to non-consensus sequences in the human genome

Fig. 3

GFP-tagged FOXM1 shows a similar genomic distribution to endogenous FOXM1. a Venn diagram showing the overlap between endogenous FOXM1 and GFP-FOXM1 binding sites in TetR HEK293 cells, using peaks in common in two replicates for each condition. b Motifs enriched in FOXM1 and GFP-FOXM1. Selected motifs identified in FOXM1 are also found in the GFP-FOXM1 peaks (full list in Additional file 1: Table S2). P values and percentages in brackets represent the statistical significance and the percentage of peaks for each motif, respectively. Motif sequences are sorted according to their proportional representation in FOXM1 peaks. c Examples of genomic regions showing three representative sites in common for endogenous FOXM1 and GFP-FOXM1 binding. d CEAS analysis comparing genomic distribution of endogenous FOXM1 binding events to GFP-FOXM1 in HEK293 cells

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