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Fig. 3 | Genome Biology

Fig. 3

From: Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

Fig. 3

Heterogeneous expression patterns of SNVs in PDX cells. a Expressed, tumor-specific, non-synonymous somatic mutations found in more than three single cells of LC-PT-45. The replicate batch (LC-PT-45-Re) of single-cell RNA-seq and that of genotyping PCR are shown together. The bar graphs at top left show mutation events per sample; the heat maps at bottom left show mutation profiles across samples; the bar graphs at the right show normalized mutation fraction over total single cells (LC-PT-45, nā€‰=ā€‰34; LC-PT-45-Re, nā€‰=ā€‰43). b Mapping information from RNA-seq for reads mapped to the human reference genome (hg19). The bar graph (left y-axis) shows the number of RNA-seq reads and the scatter plots (right y-axis) with a connecting line show the unique mapping rate (uniquely mapped reads/input reads) in the same order as in (a). c Summary of results for the matched samples and the validated targets between RNA-seq and genotyping PCR shown in (a). See Additional file 8 for the details

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