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Table 2 Average alignment SP-error, tree error, and TC score across most full-length datasets

From: Ultra-large alignments using phylogeny-aware profiles

Method

ROSE

RNASim

Indelible

ROSE

CRW

10 AA

HomFam

HomFam

 

NT

10K

10K

AA

  

(17)

(2)

Average alignment SP-error

UPP

7.8 (1)

9.5 (1)

1.7 (2)

2.9 (1)

12.5 (1)

24.2 (1)

23.3 (1)

20.8 (2)

PASTA

7.8 (1)

15.0 (2)

0.4 (1)

3.1 (1)

12.8 (1)

24.0 (1)

22.5 (1)

17.3 (1)

MAFFT

20.6 (2)

25.5 (3)

41.4 (3)

4.9 (2)

28.3 (2)

23.5 (1)

25.3 (2)

20.7 (2)

Muscle

20.6 (2)

64.7 (5)

62.4 (4)

5.5 (3)

30.7 (3)

30.2 (2)

48.1 (4)

X

Clustal

49.2 (3)

35.3 (4)

X

6.5 (4)

43.3 (4)

24.3 (1)

27.7 (3)

29.4 (3)

Average ΔFN error

UPP

1.3 (1)

0.8 (1)

0.3 (1)

1.8 (1)

7.8 (2)

3.4 (2)

NA

NA

PASTA

1.3 (1)

0.4 (1)

<0.1 (1)

1.3 (1)

5.1 (1)

3.3 (1)

NA

NA

MAFFT

5.8 (2)

3.5 (2)

24.8 (3)

4.5 (3)

10.1 (3)

2.3 (1)

NA

NA

Muscle

8.4 (3)

7.3 (3)

32.5 (4)

3.1 (2)

5.5 (1)

12.6 (3)

NA

NA

Clustal

24.3 (4)

10.4 (4)

X

4.2 (3)

34.1 (4)

3.5 (2)

NA

NA

Average TC score

UPP

37.8 (1)

0.5 (2)

11.0 (3)

2.6 (2)

1.4 (1)

11.4 (1)

47.3 (1)

40.3 (3)

PASTA

37.8 (1)

2.3 (1)

48.0 (1)

5.4 (1)

2.3 (1)

12.1 (1)

46.1 (2)

50.0 (1)

MAFFT

31.4 (2)

0.4 (2)

7.8 (4)

0.6 (3)

0.7 (2)

12.1 (1)

45.5 (2)

46.9 (2)

Muscle

9.8 (3)

<0.0 (2)

18.3 (2)

2.7 (2)

0.7 (2)

10.5 (2)

27.7 (4)

X

Clustal

5.7 (4)

0.2 (2)

X

3.1 (2)

0.1 (2)

11.8 (1)

38.6 (3)

31.0 (4)

  1. We report the average alignment SP-error (the average of SPFN and SPFP errors) (top), average ΔFN error (middle), and average TC score (bottom), for the collection of full-length datasets. All scores represent percentages and so are out of 100. Results marked with an X indicate that the method failed to terminate within the time limit (24 hours on a 12-core machine). Muscle failed to align two of the HomFam datasets; we report separate average results on the 17 HomFam datasets for all methods and the two HomFam datasets for all but Muscle. We did not test tree error on the HomFam datasets (therefore, the ΔFN error is indicated by “NA”). The tier ranking for each method is shown parenthetically