Fig. 2

Both DNMT1 maintenance-dependent and -independent activities are required for attaining full methylation. a-c Correlation of CG methylation on the sense and antisense DNA strands in WT, 1KO, and DKO cells. The CG sites with coverage ≥10 on each strand were used. A two-dimensional transformation was applied and color represents two-dimensional transformated density. Cor correlation coefficient. d Distribution of bias index (see Materials and methods for details). e CHH methylation in 1KO cells unveils the existence of DNMT1 maintenance-independent patterns