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Fig. 6 | Genome Biology

Fig. 6

From: Differential connectivity of splicing activators and repressors to the human spliceosome

Fig. 6

The SRSF1 and hnRNPA1 interactomes. Visualization of the SRSF1 (a, c) and hnRNPA1 (b, d) interactomes. (a) SRSF1 and (b) hnRNPA1 interactomes in the context of the PS network. Nodes representing ligands that form nucR PPIs with the bait are in blue; nucS proteins are colored green; IP-MS baits are colored red, and the node sizes are proportional to the P in scores between each ligand and the bait. Pie charts show the number of nucR (blue) and nucS (green) bait-to-ligand interactions with P in ≥0.1 (dark) and all co-purified proteins (light). (c,d) High-probability interactions (P in ≥0.1) detected by IP-MS for (c) SRSF1 and (d) hnRNPA1. Blue nodes and edges show nucR PPIs; green nodes and edges show nucS PPIs; the baits are colored red; functionally related groups of ligands are labeled and indicated with dashed circles

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