Skip to main content

Table 1 ADAMTS genes: their chromosomal positions, major tissue expression locations, expression-inducing factors, substrates, and associations with pathologies

From: The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

Gene Location Expression Factors inducing or (repressing) expression Substrates Pathology associations
ADAMTS1 21q21 Ovary, bronchial epithelial cells, fetal lung, placenta, smooth muscle, uterus, adrenal cortex, adipocyte, ciliary ganglion, prostate, olfactory bulb, breast stromal fibroblasts and myoepithelial cells Progesterone, Brg1, IL-1, S100A8, S100A9, TNFα Aggrecan, versican, syndecan 4, TFPI-2, semaphorin 3C, nidogen-1, −2, desmocollin-3, dystroglycan, mac-2, gelatin (denatured collagen type I), amphiregulin, TGF-α, heparin-binding EGF Cancer (both pro- and anti-tumorigenic/metastatic), anti-angiogenic
ADAMTS2 5q35 Adipocyte, skeletal muscle, superior cervical ganglion, uterus, placenta, heart, liver, lung, tongue, smooth muscle, breast stromal fibroblasts Glucocorticoids (in monocytes), IL-6 Fibrillar procollagens types I-III and V Ehlers-Danlos syndrome type VIIc, dermatosparaxis (in sheep and cattle)
ADAMTS3 4q21 CD105+ endothelial cells, CD34+ cells, pineal gland, cartilage, bone, skeletal muscle, tendon, breast myoepithelial cells   Fibrillar procollagen type II, biglycan  
ADAMTS4 1q23 Ovary, spinal cord, adrenal cortex, ciliary ganglion, trigeminal ganglion, brain, retina, pancreas (islets), fetal lung, breast myoepithelial cells IL-1 + oncostatin M, TNFα, S100A8, S100A9, leptin, IL-6 Aggrecan, versican, reelin, biglycan, brevican, matrilin-3, α2-macroglobulin, COMP Arthritis
(HDAC inhibitors, pentosan polysulfate)
ADAMTS5 21q21 Adipocyte, uterus, breast myoepithelial cells IL-1, TNFα, S100A8, S100A9, leptin, IL-6 Aggrecan, versican, reelin, biglycan, matrilin-4, brevican, α2-macroglobulin Arthritis, cancer (anti-tumorigenic, anti-angiogenic)
(HDAC inhibitors)
ADAMTS6 5q12 Superior cervical ganglion, trigeminal ganglion, appendix, heart, breast myoepithelial cells TNFα, -  
ADAMTS7 5q24 Trigeminal ganglion, adrenal cortex, liver, heart, skeletal muscle, intervertebral disc, breast stromal fibroblasts PTHrP COMP Coronary artery disease (smooth muscle cell migration)
ADAMTS8 11q24 Skeletal muscle, heart, liver, superior cervical ganglion, adrenal cortex, breast stromal fibroblasts and luminal epithelial cells   Aggrecan  
ADAMTS9 3p14 Dorsal root ganglion, breast myoepithelial cells TNFα, IL1 + oncostatin M, leptin Aggrecan, versican Cancer (anti-angiogenic)
(HDAC inhibitors)
ADAMTS10 19p13 CD8+ T-cells, brain, uterus, breast stromal fibroblasts   Fibrillin-1 Weill-Marchesani syndrome
ADAMTS12 5p13 Liver, bone marrow, atrioventricular node, intervertebral disc, breast stromal fibroblasts and myoepithelial cells   COMP Cancer (pro- and anti-tumorigenic)
ADAMTS13 9q34 Liver, CD71+ early erythroid cells, lung, thyroid, breast myoepithelial cells (IL-1) vWF Thrombotic thrombocytopenic purpura
ADAMTS14 10q22 Thalamus, bone marrow, fetal thyroid, adipocyte, cerebellum, bone, skin, fibroblasts, breast myoepithelial and luminal epithelial cells   Fibrillar procollagen type I (pNα1 and pNα2 chains)  
ADAMTS15 11q24 Colon, brain, heart, uterus, musculoskeletal system, breast myoepithelial cells   Aggrecan, versican Cancer (anti-tumorigenic/metastatic, anti-angiogenic)
ADAMTS16 5p15 Breast myoepithelial cells Follicle stimulating hormone; forskolin (cAMP); - Hypertension
Transcription factors: Wilm’s tumor-1; Egr-1, Sp1
ADAMTS17 15q26 Breast myoepithelial cells   - Weill-Marchesani-like syndrome
ADAMTS18 16q23 Ciliary ganglion, heart, skin, brain, breast myoepithelial cells   -  
ADAMTS19 5q23 Dorsal root ganglion, breast myoepithelial cells   -  
ADAMTS20 2q12 Brain, appendix, heart, liver, skeletal muscle, pituitary, trigeminal ganglion, breast myoepithelial cells   Versican