Table 1 Top-ranked epithelial-stromal co-expression relationships in normal breast, ER-negative IBC, and ER-positive IBC
From: Extensive rewiring of epithelial-stromal co-expression networks in breast cancer
Normal breast | ||||
|---|---|---|---|---|
Epithelium | Stroma | T-Stat | p-value | FDR |
IPCEF1 | SPINK1 | 29.29 | 6.70e-18 | 9.17e-10 |
HSPA12A | PNMA2 | 21.15 | 3.71e-15 | 1.74e-07 |
ALDOB | PNMA2 | 21.11 | 3.85e-15 | 1.74e-07 |
SULT1E1 | PNMA2 | 20.80 | 5.09e-15 | 1.74e-07 |
DPT | SPINK1 | 19.98 | 1.10e-14 | 2.90e-07 |
SFTPB | PNMA2 | 19.83 | 1.27e-14 | 2.90e-07 |
ADAM28 | PLCL1 | 18.80 | 3.52e-14 | 6.88e-07 |
SCN11A | SYNPO2L | 18.10 | 7.18e-14 | 1.23e-06 |
HSPA12A | CFTR | 17.45 | 1.43e-13 | 2.18e-06 |
IPCEF1 | SLC4A10 | −16.73 | 3.17e-13 | 4.34e-06 |
ER-positive IBC | ||||
Epithelium | Stroma | T-Stat | p-value | FDR |
CEACAM5 | CEACAM5 | 18.05 | 4.84e-24 | 6.65e-16 |
S100A7 | S100A7 | 14.78 | 2.93e-20 | 2.01e-12 |
FAM5C | FAM5C | 14.24 | 1.42e-19 | 6.49e-12 |
BEX1 | BEX1 | 12.70 | 1.46e-17 | 5.01e-10 |
IFIH1 | IFIH1 | 11.00 | 3.55e-15 | 9.74e-08 |
AGT | AGT | 10.74 | 8.34e-15 | 1.91e-07 |
BAMBI | BAMBI | 10.62 | 1.26e-14 | 2.48e-07 |
PCDH8 | PCDH8 | 10.29 | 3.80e-14 | 6.53e-07 |
S100A8 | S100A8 | 10.06 | 8.42e-14 | 1.28e-06 |
ATHL1 | ATHL1 | 9.95 | 1.25e-13 | 1.72e-06 |
ER-negative IBC | ||||
Epithelium | Stroma | T-Stat | p-value | FDR |
ORM1 | ORM1 | 19.29 | 6.32e-17 | 8.68e-09 |
PCP4 | PCP4 | 13.95 | 1.40e-13 | 9.62e-06 |
MMP10 | MMP10 | 13.65 | 2.29e-13 | 1.05e-05 |
DSC3 | DSC3 | 13.39 | 3.53e-13 | 1.21e-05 |
NPY5R | CPB1 | 12.46 | 1.82e-12 | 4.99e-05 |
IMPA2 | IMPA2 | 12.10 | 3.46e-12 | 7.91e-05 |
ASPM | SRPK1 | 12.02 | 4.07e-12 | 7.99e-05 |
LCN2 | LCN2 | 11.83 | 5.72e-12 | 9.81e-05 |
KRT16 | KRT16 | 11.37 | 1.36e-11 | 2.08e-04 |
SH3GL2 | SH3GL2 | 11.31 | 1.55e-11 | 2.13e-04 |