Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression

Fig. 2

Epigenetic modifications around ZFP57 peaks. a Overlap of ZFP57 peaks with Ensembl annotated gene features (left) and repeat elements (right). Selective enrichment/depletion of ZFP57 peaks are compared against an average of ten independently generated boot-strap sets (Control). b Plot of cumulative read counts for three different histone modifications around ZFP57 peaks found at imprinted germline DMRs and elsewhere. Shown are H3K4me3, H3K9me3 and H4K20me3, and pan-H3 representing overall histone density. c Average DNA methylation at CGIs bound by ZFP57 at ICRs and other non-imprinted loci compared with a randomly selected set of similar size. Data points represent individual CGIs with a horizontal line showing median value for the group. Previously published ES cell reduced representation bisulfite sequencing methylation data were used for this analysis [31]. Non-parametric Kruskall-Wallis tests were performed with significantly different categories denoted (***P < 0.001)

Back to article page