Fig. 7
From: Inferring regulatory element landscapes and transcription factor networks from cancer methylomes
High RUNX1 expression is associated with poor survival in clear cell renal carcinoma. a Shown are scatter plots for the average DNA methylation at hypomethylated-paired probes containing a RUNX motif, plotted against expression for RUNX family members RUNX1, RUNX2, and RUNX3. The number (and percentage) of hypomethylated-paired probes having a RUNX motif in each cancer type is indicated underneath the name of each cancer type. b The ranked TF plot, as described in Fig. 6, is plotted for the RUNX motif in clear cell renal carcinoma (KIRC); RUNX1, RUNX2, and RUNX3 are all within the top 5 % (dotted line) of all TFs. (c) Kaplan-Meier survival curves for TCGA KIRC samples, stratified by expression of RUNX1 (left), RUNX2 (middle), or RUNX3 (right). In each plot, the survival data for patients having tumors with the highest (top 30 %) vs. lowest (bottom 30 %) expression for the given RUNX family member is shown; the Log-Rank test P value between the high and low groups is indicated