Figure 1

Concordance of chromatin structure at multiple scales over three human cell types. The eigenvector compartment profile is shown for chromosome 2 for three human cell types (left). Genome-wide Pearson correlation coefficients between eigenvectors at 1-Mb resolution are in the range 0.75 to 0.80 (Additional file 1: Figure S2B). At higher resolution, the zoomed region illustrates conservation of topological domains (TADs) over 20 Mb of the same chromosome. Genome-wide, 33% of all H1 TAD boundaries have a matching boundary in GM12878 in the same or an adjacent 40-kb bin (K562: 31%, null model: 18%; Kolmogorov–Smirnov test: D=0.26, p≈0). Similarly, for H1 compartment boundaries, 37% have a matching boundary in the same or an adjacent 100-kb bin in GM12878 (K562: 35%, null model: 7%; Kolmogorov–Smirnov test: D=0.47, p≈0, Additional file 1: Figure S2A). Mb, megabases; TAD, topological domain.