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Table 1 The 10 most significant SoC-associated DMRs (SoC-DMRs) identified by the bump hunting analysis

From: Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

Chr SoC-DMR start SoC-DMR end Mean coefficient Probes in SoC-DMR Probes in cluster SoC P -value SoC P -value (FWER) Gene Annotation
5 135,415,762 135,416,613 0.61 15 15 2.0E-05 0.009 VTRNA2-1 Overlaps TSS
2 113,992,762 113,993,313 0.47 8 8 5.5E-04 0.228 PAX8* Intron/exon
5 23,507,030 23,507,752 0.36 12 13 8.7E-04 0.349 PRDM9 Overlaps TSS
6 32,729,442 32,729,847 0.14 20 36 1.6E-03 0.576 HLA-DQB2 Intron/exon
17 17,109,570 17,110,120 0.38 8 11 1.8E-03 0.578 PLD6 Overlaps TSS
6 29,648,345 29,649,024 0.27 14 18 1.8E-03 0.601 ZFP57* ~3 kb upstream of TSS
6 151,646,312 151,647,133 0.30 9 9 2.8E-03 0.733 AKAP12 Overlaps TSS
12 57,040,045 57,040,204 0.36 4 9 3.2E-03 0.782 ATP5B* Promoter
5 191,242 192,103 0.26 10 11 3.8E-03 0.848 LRRC14B Overlaps TSS
13 36,944,640 36,944,649 0.36 2 8 4.4E-03 0.864 SPG20 Promoter
  1. Analysis includes adjustment for sex and estimated white blood cell composition. Gene annotations are those provided by Illumina, except for entries marked with an asterisk, for which overlapping or proximal genes are listed. TSS, transcription start site.