Table 1 The 10 most significant SoC-associated DMRs (SoC-DMRs) identified by the bump hunting analysis
Chr | SoC-DMR start | SoC-DMR end | Mean coefficient | Probes in SoC-DMR | Probes in cluster | SoC P -value | SoC P -value (FWER) | Gene | Annotation |
|---|---|---|---|---|---|---|---|---|---|
5 | 135,415,762 | 135,416,613 | 0.61 | 15 | 15 | 2.0E-05 | 0.009 | VTRNA2-1 | Overlaps TSS |
2 | 113,992,762 | 113,993,313 | 0.47 | 8 | 8 | 5.5E-04 | 0.228 | PAX8* | Intron/exon |
5 | 23,507,030 | 23,507,752 | 0.36 | 12 | 13 | 8.7E-04 | 0.349 | PRDM9 | Overlaps TSS |
6 | 32,729,442 | 32,729,847 | 0.14 | 20 | 36 | 1.6E-03 | 0.576 | HLA-DQB2 | Intron/exon |
17 | 17,109,570 | 17,110,120 | 0.38 | 8 | 11 | 1.8E-03 | 0.578 | PLD6 | Overlaps TSS |
6 | 29,648,345 | 29,649,024 | 0.27 | 14 | 18 | 1.8E-03 | 0.601 | ZFP57* | ~3 kb upstream of TSS |
6 | 151,646,312 | 151,647,133 | 0.30 | 9 | 9 | 2.8E-03 | 0.733 | AKAP12 | Overlaps TSS |
12 | 57,040,045 | 57,040,204 | 0.36 | 4 | 9 | 3.2E-03 | 0.782 | ATP5B* | Promoter |
5 | 191,242 | 192,103 | 0.26 | 10 | 11 | 3.8E-03 | 0.848 | LRRC14B | Overlaps TSS |
13 | 36,944,640 | 36,944,649 | 0.36 | 2 | 8 | 4.4E-03 | 0.864 | SPG20 | Promoter |