Distribution of CGIs and repetitive elements in ME versus non-ME genomic regions. In each pair of plots, 20 kb regions centered on ME bins (SIVI ≥ 20, n = 109, right) are compared with 20 kb regions centered on comparable non-ME bins genomewide (SIVI = -5 to 5, n = 298,979, left). For each 500 bp window, the normalized overlap score is the number of elements that overlap such windows, divided by the total number of bins. (a) ME regions are slightly depleted of CGIs (P = 2.5 × 10-6). (b) ME regions are depleted of SINE elements (P = 2.5 × 10-28). (c) ME regions are enriched for LINE elements (P = 7.0 × 10-8). (d) ME regions are enriched for ERVs (P = 3.5 × 10-15). All P-values based on chi-squared test.