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Table 6 Comparison of gene annotation enrichment analyses for BRAT-associated mRNAs and mRNAs upregulated in brat mutant embryos in Classes A, B, and C

From: Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

  All BRAT-associated mRNAs mRNAs associated only with BRAT PUM and BRAT co-target mRNAs mRNAs upregulated in brat mutant embryos
  Class A Class B Class C
Biological and developmental
Embryonic pattern specification/Axis specification + . + . . +
Neuroblast fate determination . . + . . .
Cellular
Cell motility/cell migration . . + . . .
Molecular
Signal transduction + . +++ . . +
Regulation of transcription . . + . . .
Protein kinase activity + . . . . +
Phosphatase activity + . . . . +
Integral membrane proteins +++++ +++ +++ . + .
Ion transport/homeostasis +++ ++ + . +++ .
Phospholipid/phosphoinositide metabolism +++ +++ . . + .
  1. + FDR = 1% to 10%; ++ FDR = 0.1% to 1%; +++ FDR = 0.001% to 0.1%; ++++ FDR = 10−5% to 0.001%; +++++ FDR <10−5%; ‘.’ = not significant (FDR >10% and Benjamini P value >0.1). FDR values represent the most significantly enriched annotation term related to the function listed. Analyses were performed using the DAVID functional annotation tool [42,43]. For details see Additional files 8 and 16.