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Table 4 Summary of comparisons to BRAT-associated mRNAs and of BRAT-binding motif enrichment tests for transcripts up- or downregulated in brat mutant embryos

From: Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

  Upregulated in brat mutant embryos Downregulated in brat mutant embryos
0-1.5 h 1.5-3 h 3-4.5 h 4.5-6 h 0-1.5 h 1.5-3 h 3-4.5 h 4.5-6 h
Overlap with BRAT-associated mRNAsa . ++++ ++++ ++++ . . - - - - - -
Enrichment of BRAT-binding sites in 3’UTRb . +++ +++ + . - - - - - - - - - -
  1. (+) or (−) P = 0.01 to 0.05; (++) or (− −) P = 0.001 to 0.01; (+++) or (− − −) P = 10−10 to 0.001; (++++) or (− − − −) P = 10−10 to 10−22; (+) symbols indicate significant overlap or enrichment, (−) symbols indicate significant non-overlap or depletion; ‘.’ = not significant (that is, P >0.05).
  2. a P values are Bonferroni-corrected Fisher’s exact test. For complete details of comparisons see Additional file 12.
  3. b P values are Bonferroni-corrected WMW P values. For complete details of comparisons, including AUROCs, see Additional file 12.